A recent review on the mechanisms of CDDP resistance in cancer cells by Devarajan et al. [68] highlighted one mechanism by which cancer cell resistance develops that involves increased formation of reactive oxygen species, subsequent increased expression of the transcription factor nuclear factor-erythroid factor 2-related factor 2 (Nrf2), and subsequent induction of the two subunits of γ-glutamyl-cysteine synthetase, which in turn results in increased concentrations of GSH. This evidence concerns the gene NFE2L2 and cancer.