However, none of around 260 mutations in the coding regions of DPP III gene listed in cBioPortal cancer genomic database (https://www.cbioportal.org/ (accessed on 17 December 2021)), have been considered as cancer drivers, yet, while 468 of more than 1300 mutants of KEAP1, and 602 of around 1000 mutations in NRF2 listed in this database are regarded as cancer drivers indicating that mutational inactivation might be a common mechanism of the KEAP1-NRF2 signaling disruption in cancer. This evidence concerns the gene KEAP1 and cancer.