IAPP and pancreatic insulinoma: For instance, pentapeptide FLPNF, which binds within the membrane-binding domain and self-association region of the N- and C-terminus, respectively, was reported to increase the viability of cultured rat insulinoma cells [35] This illustrates the potential of targeting the non-amyloidogenic regions of IAPP as an alternative mechanism in the development of novel anti-fibrillation agents.