PRKCA and Anxiety: Equipped with a mouse model of anxiety (5-HT1A-R-/- mice) and a 5-HT1A-R-expressing hippocampal neuron-derived cell line, HN2-5, our earlier studies have reported that a 5-HT1A-R-mediated signaling pathway functions via extracellular receptor-activated kinase 1/2 (ERK1/2)-catalyzed activation of protein kinase C alpha (PKCα) to promote synaptogenesis at P15 in the hippocampal CA1 region [12,16].