We asked here whether syncytia formation was inhibited by transfection with 2′-O-methyl antisense RNA, as the cellular model of infection (HEK293T-ACE2 cells), mainly because the S protein is very low in cells infected by SARS-CoV-2, and this would affect syncytia formation by impairing the ACE2-S protein interactions that prime syncytia formation. The gene discussed is ACE2; the disease is infection.