Altogether, an important factor to highlight from this analysis is that SFN encapsulated in BM-vesicles showed a protective anti-inflammatory activity, as shown by the high levels of TNF-α, IL-1β and IL-6 inhibition with very low cytotoxicity, thus providing a natural alternative for treating chronic inflammatory diseases, such as endometriosis [11], among others [28]. The gene discussed is TNF; the disease is endometriosis.