Since A20 overexpression rescued the fibrotic response in primary TM cells, we next tested the role of A20 in our in vivo mouse model of glaucoma: B6.EDA+/+ mice, which constitutively express the known DAMP FN-EDA and develop ocular hypertension and TM damage [5,19]. The gene discussed is TNFAIP3; the disease is ocular hypertension.