At this point in time, the currently approved COVID-19 vaccines, such as NVX-CoV2373 and EpiVacCorona (S protein-based vaccines), CoronaVac and BBIBP-CorV (inactivated vaccines), have shown decreased protection against variants of concern (VOCs) of SARS-CoV-2, and there have been increasing numbers of breakthrough infections with VOCs in the vaccinated population [10]. The gene discussed is PROS1; the disease is infection.