The SARS-CoV-2 S protein formulated with Advax-SM, a combination adjuvant consisting of delta inulin polysaccharide particles (AdvaxTM) and a TLR9-active oligonucleotide-CpG55.2, induced neutralizing antibodies in mice that could neutralize infection by the SARS-CoV-2 wildtype lineage B.1.319 and cross-neutralize the VOC Alpha (B.1.1.7), and protected ferrets against SARS-CoV-2 infection [44]. The gene discussed is PROS1; the disease is infection.