A representative member of the GFR family—fibroblast growth factor receptors (FGFRs)—are TKRs that play an important role in cell proliferation, migration, differentiation, and carcinogenesis [80], and are also found to be relevant in viral infections, for example, during endocytosis of the adeno-associated virus 2, and can be considered as a reserve receptor for SARS-CoV-2. This evidence concerns the gene RAPGEF5 and viral infectious disease.