CPSF6 and HIV-1 infection: Expression of a cytosolic fragment of CPSF6 [CPSF6(1–358)] was found to potently block human immunodeficiency virus-1 (HIV-1) infection before the formation of 2-long terminal repeat circles [1], and this inhibition of HIV-1 infection correlated with the ability of CPSF6(1–358) to bind to the capsid and prevent uncoating [2,3,4].