PEX11A and Zika virus infectious disease: While we and other groups have shown that complete and partial peroxisome loss results in impaired flavivirus replication [17,18], suggesting a pro-viral role of peroxisomes in infection, another study showed that an increase in peroxisome numbers, by overexpression of PEX11, has an anti-viral effect against ZIKV infection, likely due to an increase in the peroxisome-dependent innate immune response [19].