Since pregnancy is a unique modulated immunological condition, with high levels of TGF-β in the circulation and in the placenta, and since, as mentioned before, ZIKV infection induces high circulating levels of IL-6 and IL-1β, we can suggest that the priming of CD4 T cells of the Th1Th17 phenotype may have happened during the mothers’ pregnancies, especially among the mothers who gave birth to children with CZS and among their children, regardless of clinical impairment. The gene discussed is CD4; the disease is Zika virus infectious disease.