CD8A and Zika virus infectious disease: Further confirming this phenomena, a study showed that immunizing ifnar−/− HLA-transgenic mice (i.e., HLA-B*07/02 and HLA-A*0101) with immunodominant peptides elicited a higher CD8 T cell response with lower ZIKV titers in the serum and brain, highlighting the role of CD8+ T cells in the neuropathology of ZIKV infection [108].