Spadaro et al. showed that plasma levels of endothelial damage markers such as angiopoietin-2 (ANG-2), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and E-selectin were higher in patients with ARDS caused by COVID-19 than in patients with ARDS of other etiologies [16]. Here, ANGPT2 is linked to COVID-19.