The hnRNP K and Gemin5 inhibit the FMDV IRES [256,257], while the double-stranded RNA-binding protein 76 (DRBP76, also known as NF90/NFAR-1, and ILF3), when heterodimerized with the nuclear factor of activated T cells, 45 kDa (NF45), selectively blocks HRV2 IRES-driven translation initiation in neuronal cells, but not in glioma cells [258]. The gene discussed is ILF3; the disease is central nervous system cancer.