TGFB1 and neoplasm: However, TFA damage may be especially harmful through enhancing transforming growth factor-beta (TGF-β) production in case of solitary fibrous tumors, neoplasms (angiomyolipoma, leiomyoma, hemangioma, lymphangioma, juxtaglomerular cell tumor, renomedullary interstitial cell tumor, lipoma, and schwannoma), and malignant tumors (leiomyosarcoma, rhabdomyosarcoma, angiosarcoma, osteosarcoma, synovial sarcoma, fibrosarcoma, malignant fibrous histiocytoma) arising from renal mesangial cells [20].