SIRT1 and Hyperglycemia: In summary, high EVOO intake with diet decreases the likelihood of cancer and increases life expectancy because EVOO can counteract DMBA and TFA-induced damage by improving global DNA methylation pattern, while decreasing hyperglycemia, mTOR activity, and inducing SIRT1 function among other [11,12,97,103,106,158] (Figure 4).