The expression level of miR-9 is increased by C-MYC, and miR-9 inhibits the progression of HCC as a tumor suppressor, but miR-9 also amplifies E-cadherin, which increases C-MYC expression, which increases miR-9 level, forming a positive feedback loop [93,98]. The gene discussed is CDH1; the disease is hepatocellular carcinoma.