A 6-month clinical trial conducted in Denmark in a controlled, free-living setting and involving obese participants (n = 64; mean age 44 years) showed that NND compared to an average Danish diet was associated with an improvement in insulin resistance index, which provides the possibility of using NND as a strategy to prevent the onset of T2D in obese persons at risk [151]. This evidence concerns the gene INS and type 2 diabetes mellitus.