Among several species of hawthorn, haw pectin and polyphenols from C. pinnatifida regulate AMPK/SIRT1/NFκB and NIK/IKK/NFκB signaling against high-fat-diet-induced hepatic inflammation, confirming their applicability in NASH treatment [77,82] (Figure 3, Table 3). The gene discussed is NFKB1; the disease is metabolic dysfunction-associated steatohepatitis.