Third, 5AMP-activated protein kinase (AMPK) signaling, a highly attractive target for glucolipid homeostasis to reduce hepatic steatosis, is involved in the benefits of haw pectin against fat overload in liver tissue, and PPARα, SIRT1, and NFκB may be closely associated with AMPK-dependent regulation of haw pectin in high-fat-diet-induced hepatic steatosis [34,53,76,77] (Figure 2, Table 2). Here, PPARA is linked to fatty liver disease.