Yet within that 88% of runners who will receive no benefit from the chronic ingestion of high-carbohydrate diets, there will be many who are insulin resistant and at risk of developing NAFLD and T2DM should they habitually eat that high-carbohydrate diet and include the regular consumption of HFCS-containing ‘sports’ drinks. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.