In late 2016, Burnett and colleagues showed that NHLH2 and PCSK1 (PC1/3) mRNAs and proteins were downregulated in PWS-derived induced pluripotent stem cell neurons (iPSC), and in the PWS mouse model, the Snord116m+/p− mouse [3]. Here, NHLH2 is linked to Prader-Willi syndrome.