In response to hyperinsulinemia during the 6-h HEC, circulating BNP significantly decreased both in the normal-weight group (from 2.06 ± 0.89 pg/mL to 1.63 ± 0.89 pg/mL at 120 min (p = 0.014), then to 1.52 ± 0.65 pg/mL at 360 min (p = 0.007)) and in the overweight/obese group (from 2.97 ± 1.65 pg/mL to 2.35 ± 1.42 pg/mL at 120 min (p = 0.031), then to 2.25 ± 1.24 pg/mL at 360 min (p = 0.007), time × group interaction p = 0.90) (Figure 3A). This evidence concerns the gene NPPB and Hyperinsulinemia.