INS and type 2 diabetes mellitus: Out of the only four long-term clinical trials investigating the effects of meal frequency in T2DM, the three with caloric restrictive diets provided contradictory results: (a) in T2DM subjects receiving anti-diabetic medications, 2 large vs 6 smaller meals decreased body weight, fasting plasma glucose/C-peptide/glucagon levels, with no differences in HbA1c, insulin, insulin sensitivity and blood lipids [320].