Results from two systematic reviews and meta-analyses of 33 RCTs in healthy, overweight/obese, prediabetes, T2DM, and hyperlipidemic subjects examining the metabolic effects of inulin-type fructan intake, reported a reduction in blood glucose, total cholesterol, and triglyceride concentrations in people with diabetes, although the mechanisms were inconclusive without differences from controls on body weight and blood insulin and with data showing large heterogeneity [411,412]. This evidence concerns the gene INS and diabetes mellitus.