PTPRC and Huntington disease: Lastly, caffeic acid phenethyl (30 mg/kg) has shown to be neuroprotective by counteracting 3-nitropropionic acid-induced striatal neurotoxicity, representing a model of Huntington’s disease (HD) [31]; it reduced striatal damage and the behavioral deficits also reducing the activation of astrocyte (glial fibrillary acidic protein; GFAP) and microglia (CD45).