An in vivo study by Güven et al. demonstrated that syringic acid treatment (10 mg/kg b.w., i.p.)in a cerebral ischemia model induced by artery occlusion reduced oxidative stress and neuronal degeneration by increasing the activity of SOD and the levels of NRF-1, while reducing MDA, caspase-3, and caspase-9 levels [109]. This evidence concerns the gene NRF1 and brain ischemia.