CDK4 and cancer: Furthermore, the anti-cancer effect of the sea cucumber intestinal peptide has been shown to be modulated through inhibiting the overexpression of EGFR, PI3K, AKT1, and CDK4 and through inhibiting the malignancy of lung cancer by regulating miR-378a-5p-targeted tumor suppressor candidate gene 2 (TUSC2) [50,51].