UKCR showed strong correlations with intrarenal KIM-1, renal oxidative stress, and structural abnormalities at week 32, suggesting that this was a reliable marker to classify the stage of DKD progression, and this is consistent with human studies in which KIM-1 predicts early kidney functional decline as well as end-stage kidney disease [20,21,32]. This evidence concerns the gene HAVCR1 and diabetic kidney disease.