Systematic review and meta-analysis showed that a ML significantly improved chronic inflammation markers such as CRP, pro-inflammatory cytokines such as IL-6, and adiponectin (AD), as well as endothelial function parameters, such as intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-Selectin [49]. Here, ICAM1 is linked to Alzheimer disease.