During immune surveillance, contact between an antigen-presenting cell (APC) and a cytotoxic T cell is essential and leads to formation of the immunological synapse that results in vesicle transport of soluble agents and membrane proteins within this zone of cell–cell contact that is needed to secrete cytokines, perforin, etc., to regulate immune response and induce apoptosis of tumor cells [79]. This evidence concerns the gene PRF1 and neoplasm.