NPC1 and infection: Because host cell cholesterol balance has been observed to exert a pivotal role in the infection cycles of several enveloped viruses including Ebola and influenza viruses [25,50,51], analyzing the relationships between the chemical structure of itraconazole and its biological activity (i.e., blocking NPC1 functionality) appears the path forward, and by understanding the structure–activity relationships (SAR), molecular docking simulation can then be used to rationally design novel antiviral derivatives.