A study with Agaricus bisporus powder (6 dosages starting with 4 g/d, and the maximum dosage capped at 14 g/d) in prostate cancer patients (n = 32) included several parameters such as evaluation of toxicity, effect on serum PSA/androgen levels and cytokine levels, etc. The extract appeared to reduce prostate cancer by reducing immunosuppressive factors [10] (Supplementary Materials, Table S1). This evidence concerns the gene KLK3 and prostate cancer.