TIMP1 and neoplasm: Andrographis paniculata extract and andrographolide inhibit tumor-specific angiogenesis by regulating the production of various pro and antiangiogenic factors such as proinflammatory cytokines, nitric oxide, vascular endothelial growth factor (VEGF), interleukin (IL)-2 and tissue inhibitor of metalloproteinase-1 [124,125].