HMGB1 and Sepsis: In an animal model that attempts to mimic the massive release of bacterial LPS sometimes observed in clinical sepsis [133], Peek et al., in their article published in Pharmaceuticals, focused on the High Mobility Group Box-1 Protein (HMGB-1), a nuclear DNA-binding protein that alters the structure of chromatin, but which can serve as a danger-associated molecular pattern or alarmin and mimic pro-inflammatory cytokine activity when present in the extracellular space [134].