Induction of BPH by testosterone for 4 weeks insignificantly reduced serum luteinizing hormone (LH) concentrations compared with the control rats (0.77 ± 0.05 vs. 1.24 ± 0.23 mIU/L, respectively, Figure 4B), while rats treated with aescin showed significantly increased serum levels of LH compared with the untreated BPH rats (1.75 ± 0.13 vs. 0.77 ± 0.05 mIU/mL, respectively). Here, PLOD1 is linked to benign prostatic hyperplasia.