As shown in Figure 8A, daily administration of testosterone (3 mg/kg, s.c.)for four weeks to induce BPH in the rats moderately elevated the serum ALT activity compared with the control rats (55.0 ± 2.55 vs. 37.0 ± 0.84 IU/L, respectively, p < 0.0001). This evidence concerns the gene GPT and benign prostatic hyperplasia.