PPARGC1A and acute kidney injury: Also, liquid chromatography–mass spectrometry (LC–MS)-based metabolomics revealed endogenous renal metabolism in mice, in which the mitochondrial biogenesis regulator, PGC1α (peroxisome proliferator-activated receptor γ coactivator 1-α), was a key determinant of kidney recovery from AKI through the regulation of nicotinamide adenine dinucleotide (NAD) biosynthesis [44,45].