Our findings showing that JQ1 inhibited Grem-1 and the gene transcription of NOTCH-effectors (Hes-1 and Hey-1) in experimental NTS nephritis, together with previous studies showing inhibition NF-κB/proinflammatory genes (as now also shown for Ccl8) [32], support further research on epigenetic drugs, such as iBETs, for rapidly progressive cGN. Here, HEY1 is linked to childhood gender nonconformity.