Since Gremlin-1 activates NF-κB and NOTCH pathways in the kidney [20], we postulate that the JQ1-mediated decrease in Grem-1 transcription could also potentially inhibit the Gremlin-mediated activation of both NF-κB and NOTCH pathways, and therefore, their contribution to CKD progression. The gene discussed is NFKB1; the disease is chronic kidney disease.