In order to find differences in clinical manifestations presented by the recent dengue cases, we analyzed symptoms reported by three different groups: chikungunya cases (anti-CHIKV IgM and/or RT-qPCR positive), recent dengue (anti-DENV IgM and/or NS1 positive), and chikungunya/dengue cases (simultaneously positive by any laboratorial method). This evidence concerns the gene CD40LG and dengue disease.