IL6 and cancer: In addition, IL-6 and miR-31 expression are closely co-regulated: IL-6 was shown to activate the Hippo pathway and to upregulate miR-31-5p, resulting in experimental cancer in mice [61]; at the same time, downregulation of miR-31-5p attenuated IL-6 production and release in LPS-induced murine acute lung injury [62].