TLR7 and infection: On the other hand, sole infection with the mutant moderately virulent isolate resulted in up-regulation of MyD88 and TANK-binding kinase 1 binding protein (TBKBP1, also known as SINTAD) genes in the nervous tissues of the fish, suggesting that the viral recognition happens through TLRs (TLR7, 8 or 9), adaptor (MyD88), and the TBKBP1 [49].