IRF3 and infection: Garcia Belmonte and colleagues highlighted the role of the cGAS-STING-IRF3 route in ASFV infection and the differences in innate immune response between virulent and attenuated ASFV strains, by demonstrating that the attenuated NH/P68 strain activates the cGAS-STING-IRF3 cascade early during infection, resulting in the induction of significant levels of IFN-β in infected macrophages, whereas virulent Arm/07 strain inhibits IFN-β synthesis by modulating STING phosphorylation and subsequent IRF 3 activation [248].