IFNA1 and viral infectious disease: As for vaccines, the major difficulty in developing an effective one is mainly due to the complex nature of virus and the diversity in virulence between strains; until now, gene-deleted live attenuated vaccines (LAVs) proved to be efficient in controlling viral disease; because of the involvement of MGF genes in the inhibition of IFN production during ASFV infection, several authors have suggested that MGF360 and 505-deletedmutants could be used for immunization of pigs [250,262,270].