IFNG and severe acute respiratory syndrome: Importantly, Cameron and colleagues [144] suggested that dysregulation of innate and adaptive immune responses due to loss of homeostasis of type I (IFN-α) and type-II (IFN-γ) IFNs lead to a failure of SARS-CoV clearance from the lungs in severe SARS patients at crisis, whereas resolution of IFN and IFN-stimulated gene response in non-severe SARS patients was associated with recovery.