Infection with the PAO1 strain in BEAS-2B bronchial epithelial cells decreases the expression of PGC-1α, mitochondrial transcription factor A (TFAM), the mitochondrial-localized NAD+ deacylase sirtuin 3 (SIRT3), and nuclear factor erythroid 2-related factor 2 (NRF2) (Figure 2A). Here, SIRT3 is linked to infection.