CAV1 and osteosarcoma: It has been reported that sclareol, a plant diterpene, inhibits the growth of osteosarcoma tumor cells MG63 (IC50 of 65.2 μM); inhibits cell proliferation in leukemic, breast, and HeLa cancer cells; induces apoptosis via regulation of the caveolin-1 (Cav-1) protein P13K, STAT5, and NF-kB pathways [94].