Owing to the concentrically encapsulated GOx and catalase and their deliberately arranged locations, 1% (v/v) EPMGOx-Cat can potently redress hyperglycemia from 10.5 to 5 mM in 15 min with an initial glucose consumption rate of 400 μM min−1 in mouse whole blood. The gene discussed is CAT; the disease is Hyperglycemia.