To produce a malaria vaccine, we selected the highly conserved malaria parasite proteins EXP1 (exported protein 1), TMP21 (transmembrane protein 21) and UIS3 (upregulated in infectious sporozoites), as they were the best LS exported protein candidates that showed, individually, the best results in protecting immunized mice against an infectious sporozoite challenge, and eliciting CD8 T cells in a previous DNA immunization study from our lab [5]. This evidence concerns the gene XPO1 and malaria.