CRP and obesity due to melanocortin 4 receptor deficiency: Moreover, vitamins, like C, E, D significantly modify lipid profile, modulate oxidative stress markers (oxLDL, non-esterified fatty acids, NEFA), and inflammation (C reactive protein, CRP, adiponectin, IL-6, TNF-α), involved in obesity, hypertension, CVD and T2DM [87].