Most remarkably, this gene response to malaria occurred significantly faster in the liver of vaccination-protected mice than in unvaccinated mice, evidenced at early patency on day 4 p.i., when the liver exhibited significantly higher levels of malaria-induced transcripts of the genes Selp and Pdgfb at p-values < 0.0001, Gp5 at p-value < 0.001, and Mpl, Gp1ba, Gp1bb, Gp6, Gp9, Pf4, and Clec1b at p-values < 0.01. The gene discussed is GP5; the disease is malaria.