Infection with blood-stage malaria significantly affected the amount of Tubb1 transcripts until day 4 p.i. Thereafter, however, an almost steady increase in Tubb1 mRNA occurred, reaching a maximum towards the end of the crisis phase on day 11 p.i. In vaccinated mice, however, the time course of Tubb1 expression in response to malaria appeared to be only delayed for 1 day, before the Tubb1 mRNA continuously increased towards the end of the crisis phase, but at a significantly lower rate than in unvaccinated mice. The gene discussed is TUBB1; the disease is malaria.