VWF and malaria: In unvaccinated mice, the response of Vwf expression to malaria appeared to be delayed during the prepatency phase and began to steadily increase from approximately 90 on day 4 p.i. to 150 towards the end of the crisis phase on day 11 p.i. In vaccination-protected mice, however, there was initially a significant (p-value < 0.05) decrease of Vwf expression, which was thereafter highly significantly (p-value < 0.01) increased from approximately 80 on day 1 p.i. to 105 on day 4 p.i., reaching maximal expression of 145 at peak parasitaemia on day 8 p.i.