Common to unvaccinated mice was a relatively low response of expression to blood-stage malaria until early patency on day 4 p.i., before a highly significantly increased expression at peak parasitaemia on day 8 p.i. Compared with unvaccinated mice, the liver of vaccinated mice responded to malaria at early patency on day 4 p.i. with a significantly higher expression, though at different levels of significance for Pf4 (p-value < 0.01), Selp (p-value < 0.0001), and Pdgfb (p-value < 0.001). Here, PF4 is linked to malaria.