Infection with malaria induced a slight decrease in Fli1 expression at early prepatency on day 1 p.i., before a continuous increase reaching a maximum on day 8 p.i. In vaccination-protected mice, however, the initially decreased expression of Fli1 was significantly (p-value < 0.05) lower than that in unvaccinated mice. This evidence concerns the gene FLI1 and malaria.