IL2 and coccidiosis: Employing in ovo delivery, Ding and colleagues (2004) evaluated the recombinant 3-1E protein from E. acervulina against coccidiosis in combination with plasmid carrying a gene encoding IL-1, IL-2, IL-6, IL-8, IL-15, IL-16, IL-17, IL-18, or IFN-γ.