The clinical reliability of such a role in head and neck cancer, and oropharyngeal squamous cell carcinoma in particular, is currently a relevant matter of debate [10,25,26], yet p16 overexpression is considered a reliable surrogate marker of HPV-driven carcinogenesis in the new American Joint Committee on Cancer (AJCC) staging system for oropharyngeal squamous cell carcinoma (OPSCC) [27,28]. Here, CDKN2A is linked to oropharynx squamous cell carcinoma.