MiR-US25-1-5p was confirmed to inhibit HCMV DNA replication during infection by directly interacting with a series of cellular genes, including tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (YWHAE), ubiquitin B (UBB), phosphoprotein B23 (NPM1), and eat shock protein 90 kDa alpha, class A member 1 (HSP90AA1) [93]. The gene discussed is YWHAE; the disease is infection.