▪NPs improved drug bioavailability and anticancer activity▪Significant antioxidant effects▪High tumor-targeting efficacy and distribution in MCF-7 cells▪Initiation of apoptosis and promotion of cell cycle arrest at the G2/M▪Upregulated pro-apoptotic p53, while downregulating antiapoptotic Bcl-2. The gene discussed is TP53; the disease is neoplasm.