DMR7 showed EC50 values of 0.10 ± 0.01 nM for AD-tau extracted from postmortem human brain tissue, 0.46 ± 0.32 nM for AD-tau seeded recombinant tau preformed fibrils (AD-P1 PFFs) expressed in BL21(DE3)RIL Escherichia coli, and 12.0 ± 7.9 nM for tau monomer through sandwich ELISA measures. The gene discussed is MAPT; the disease is Alzheimer disease.