The physical and pathological properties of tau are inherited from the original tau seeds, which form disease-specific tau pathology based on tau strains in AD, Pick’s disease (PiD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) [25], appearing to belong to unelucidated respective certain strains. The gene discussed is MAPT; the disease is Classical progressive supranuclear palsy.