IL1B and rheumatoid arthritis: In the same line, LPS plus IFNγ stimulation of PBMCs from HG showed a tendency to increase mRNA levels of all cytokines/chemokines under study, which was not verified for RA patients; as result, in RA patients, the cytokine’s mRNA expression upon cell activation was significantly lower as compared to HG (p < 0.05), except for IL-1β in non-classical monocytes (Figure 6).